A pharmacy advertises the COVID-19 vaccine as the nation marks the fifth anniversary of the Covid-19 pandemic on March 13, 2025 in New York City

A pharmacy advertises the COVID-19 vaccine as the nation marks the fifth anniversary of the Covid-19 pandemic on March 13, 2025 in New York City

The United States will limit Covid-19 boosters to people over 65 or those at risk of serious illness, while requiring vaccine makers to run fresh clinical trials before offering shots to younger and healthier individuals, officials said Tuesday.

Writing in the New England Journal of Medicine, the Food and Drug Administration's Vinayak Prasad and Commissioner Martin Makary framed the policy shift as "evidence-based" and would align the United States more closely with guidance in Europe.

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