Manchester City, Chelsea and Newcastle secured places in next season's Champions League as Liverpool lifted the Premier League trophy after a 1-1 draw against Crystal Palace on a dramatic final day of the season on Sunday.
Crystal Palace stunned Manchester City on Saturday to win the FA Cup for the first time as Eberechi Eze sealed a 1-0 victory that piled on the misery for Pep Guardiola's troubled side.
Liverpool have wrapped up the Premier League title and the three relegated teams know their fate but the fight for the top five is reaching a climax.
Liverpool slumped to just their second Premier League defeat this season as Fulham clinched a shock 3-2 win over the runaway leaders, while Southampton were relegated in record-setting time after a 3-1 loss at Tottenham on Sunday.
The battle for a place in the Champions League is the focus of attention in the final two months of the Premier League season with the title race and relegation battle seemingly a foregone conclusion.
Manchester City face Bournemouth in the FA Cup quarter-finals aiming to keep alive their last chance of silverware in a turbulent season.
Chelsea's challenge for a place in next season's Champions League faltered in a toothless 1-0 defeat at Arsenal on Sunday as Manchester United continued their upward trend with a 3-0 win at Leicester.
Manchester City's hopes of a trophy this season now rest solely on the FA Cup ahead of Saturday's visit of second-tier Plymouth, while holders Manchester United also desperately need silverware to rescue a miserable campaign.
Chelsea moved into the Premier League's top four with a 4-0 demolition of hapless Southampton, but Aston Villa's hopes of Champions League football next season diminished after a 4-1 defeat at Crystal Palace.
Kevin De Bruyne spared Manchester City's blushes with a late strike to beat third tier Leyton Orient 2-1 in the FA Cup fourth round on Saturday, while Newcastle also came from behind to win 3-2 at Birmingham.